4-Chloro-3-cresol (PCMC) home ICD10: L23.9

4-Chloro-3-cresol (PCMC)

Formula CAS
C7H7ClO 59-50-7


Background
4-Chloro-3-cresol is an antiseptic, desinfectans, and fungicide.

Synonyms
4-Chloro-3-cresol
4-Chloro-3-methylphenol
3-Methyl-4-chlorophenol
2-Chloro-5-hydroxytoluene
6-Chloro-m-cresol
6-Chloro-3-hydroxytoluene
Chlorocresol
Ottafect
p-Chloro-M-Cresol
Parachlorometacresol
PCMC
Phenol, 4-chloro-3-methyl
Preventol CMK

Uses
Adhesives and glues
Baby cosmetics
Cooling fluids
Cosmetics (shampoos and baby cosmetics)
Creams
Inks, paints, and varnishes
Metalworking fluids
Packing materials
Pharmaceutical products (corticosteroid creams)
Tanning agents
Textile finishes
Topical antiseptics and disinfectants

Cross-Reactions
4-chloro3-xylenol

Unusual Reactions
Immunologic contact urticaria Non-immunologic contact urticaria

Back to list of contact allergens


Referenties
1. Oleffe JA, Blondeel A, de Coninck A. Allergy to chlorocresol and propylene glycol in a steroid cream. Contact Dermatitis 1979 Jan;5(1):53-54.
2. Dooms-Goossens A, Degreef H, Vanhee J, Kerkhofs L, Chrispeels MT. Chlorocresol and chloracetamide: allergens in medications, glues, and cosmetics. Contact Dermatitis 1981 Jan;7(1):51-52.
3. Andersen KE, Hamann K. How sensitizing is chlorocresol? Allergy tests in guinea pigs versus the clinical experience. Contact Dermatitis 1984 Jul;11(1):11-20.
4. Archer CB, MacDonald DM. Chlorocresol sensitivity induced by treatment of allergic contact dermatitis with steroid creams. Contact Dermatitis 1984 Sep;11(3):144-145.
5. Andersen KE, Carlsen L, Egsgaard H, Larsen E. Contact sensitivity and bioavailability of chlorocresol. Contact Dermatitis 1985 Oct;13(4):246-251.
6. Andersen KE. Contact allergy to chlorocresol, formaldehyde and other biocides. Guinea pig tests and clinical studies. Acta Derm Venereol Suppl (Stockh) 1986;125:1-21.
7. Freitas JP, Brandão FM. Contact urticaria to chlorocresol. Contact Dermatitis 1986 Oct;15(4):252.
8. Gonçalo M, Gonçalo S, Moreno A. Immediate and delayed sensitivity to chlorocresol. Contact Dermatitis 1987 Jul;17(1):46-47.
9. Lewis PG, Emmett EA. Irritant dermatitis from tri-butyl tin oxide and contact allergy from chlorocresol. Contact Dermatitis 1987 Sep;17(3):129-132.
10. Zemtsov A. et al. Evaluation of antigenic determinant in chlorocresol and chloroxylenol contact dermatitis by patch testing with chemically related substances. American Journal of Contact Dermatitis 1994;5(1):19-21.


Auteur(s):
dr. Jan R. Mekkes. Dermatoloog, Amsterdam UMC.

06-08-2024 (JRM) - www.huidziekten.nl W3C-html-4.01-valid