4-Phenylenediamine dihydrochloride

codes geen / geen

 

 

Formula

CAS

C6H4(NH2)2 . 2HCl

615-28-1

 
CAS: Chemical Abstract Service Registry Number
 

Background

4-Phenylenediamine dihydrochloride is a primary intermediate in permanent hair dyes and fur dyes.

 

Synonyms

1,4-Benzenediamine
1,4-Phenylenediamine
4-Phenylenediamine
p-Diaminobenzene
Orsin
C.I. 76076
p-Amimoaniline
p-Diaminobenzene
Rodol D
Ursol D

 

Uses

Cosmetics (permanent hair colors, some dark-colored cosmetics)
Lithography (printing inks)
Oils, greases, gasoline
Photocopying
Photographic developers
Primary intermediate in the production of azo dyes
Rarely, fur and leather dyes
Rubber and plastic industry (antioxidants and accelerators)

 

Cross-Reactions

Parabens
PABA
Para group of compounds

 

Unusual Reactions

Airborne contact dermatitis
Contact urticaria
Erythema multiforme-like reactions
Photoallergy

 

References

1.

Adams, R.M. and H.I. Maibach, A five-year study of cosmetic reactions. Journal of the American Academy of Dermatology, 1985. 13(6): p. 1062-9.

2.

Edwards, E.K., Jr. and E.K. Edwards, Contact urticaria and allergic contact dermatitis caused by paraphenylenediamine. Cutis, 1984. 34(1): p. 87-8.

3.

Foussereau, J., G. Reuter, and J. Petitjean, Is hair dyed with PPD-like dyes allergenic?. Contact Dermatitis, 1980. 6(2): p. 143.

4.

Lynde, C.W. and J.C. Mitchell, Patch test results in 66 hairdressers 1973--81. Contact Dermatitis, 1982. 8(5): p. 302-7.

5.

Maibach, H.I., Paraphenylenediamine-free hair coloring mousse. Contact Dermatitis, 1986. 15(2): p. 103.

6.

Matsunaga, K., et al., Occupational allergic contact dermatitis in beauticians. Contact Dermatitis, 1988. 18(2): p. 94-6.

7.

Nethercott, J.R., et al., Contact dermatitis in hairdressers. Contact Dermatitis, 1986. 14(2): p. 73-9.

8.

Picardo, M., et al., Paraphenylenediamine, a contact allergen, induces oxidative stress and ICAM-1 expression in human keratinocytes. British Journal of Dermatology, 1992. 126(5): p. 450-5.

9.

Shimunes, E., Purpuric allergic contact dermatitis to paraphenylenediamine. Contact Dermatitis, 1978. 4(4): p. 225-9.

10.

Sutthipisal, N., J.P. McFadden, and E. Cronin, Sensitization in atopic and non-atopic hairdressers with hand eczema. Contact Dermatitis, 1993. 29(4): p. 206-9.

11.

Temesvari, E., Contact urticaria from paraphenylenediamine. Contact Dermatitis, 1984. 11(2): p. 125.

12.

Storrs, F.J., et al., Paraphenylenediamine dihydrochloride. Contact Dermatitis, 1979. 5(2): p. 126.

13.

Storrs, F.J., et al., Prevalence and relevance of allergic reactions in patients patch tested in North America--1984 to 1985. Journal of the American Academy of Dermatology, 1989. 20(6): p. 1038-45.

 

 

 

 

 

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