|
Formula |
CAS |
|
C5H6O |
547-65-9 |
CAS: Chemical Abstract Service Registry Number
Background
a-Methylene-g-butyrolactone
(Tulipalin A) is released from a glucoside
precursor known as tuliposide A. It is the allergen in the Liliaceae and
Alstroemeriaceae family of plants.
Dermatitis is a common occupational hazard of tulip bulb handlers.
It characteristically affects the distal end of the thumb and forefingers.
This painful, dry fissured hyperkeratotic dermatitis is known as tulip
fingers.
Synonyms
a-Methylene-g-butyrolactone
a-Methylene butyrolactone
Tuliposide A
4,5-Dihydro-3-methylene-2(3H)-furanone
alpha-Methylene--gamma-butyrolactone
Uses
Plant allergen
Cross-Reactions
Unusual Reactions
Depigmentation
References
|
1. |
Benezra, C., Synthetic alpha-methylene-gammabutyrolactone, immunological activity. Contact Dermatitis, 1978. 4(4): p. 242. |
|
2. |
Stampf, J.L., G. Schlewer, and C. Benezra, Animal and human sensitivity to alpha-methylene-gamma-butyrolactone derivatives. Contact Dermatitis, 1978. 4(5): p. 306-7. |
|
3. |
Stampf, J.L., et al., Allergic contact dermatitis due to sesquiterpene lactones. A comparative study of human and animal sensitivity to alpha-methylene-gamma-butyrolactone and derivatives. British Journal of Dermatology, 1978. 99(2): p. 163-9. |
|
4. |
Santucci, B., et al., Contact dermatitis to Alstroemeria. Contact Dermatitis, 1985. 12(4): p. 215-9. |
|
5. |
Schaeffer, M., et al., Cross-reaction in allergic contact dermatitis from alpha-methylene-gamma-butyrolactones: importance of the cis or trans ring junction. Contact Dermatitis, 1990. 22(1): p. 32-6. |
|
6. |
Gette, M.T. and J.E. Marks, Jr., Tulip fingers. Archives of Dermatology, 1990. 126(2): p. 203-5. |
|
7. |
Marks, J.G., Jr., Allergic contact dermatitis to Alstroemeria. Archives of Dermatology, 1988. 124(6): p. 914-6. |
|
8. |
Thiboutot, D.M., B.H. Hamory, and J.G. Marks, Jr., Dermatoses among floral shop workers. Journal of the American Academy of Dermatology, 1990. 22(1): p. 54-8. |
|
9. |
Lahti, A., Contact urticaria and respiratory symptoms from tulips and lilies. Contact Dermatitis, 1986. 14(5): p. 317-9. |
|
10. |
Bruynzeel, D.P., et al., Dermatitis in bulb growers. Contact Dermatitis, 1993. 29(1): p. 11-5. |
13-08-2011
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