Formula |
CAS |
C5H6O |
547-65-9 |
CAS: Chemical Abstract Service Registry Number
Background
a-Methylene-g-butyrolactone
(Tulipalin A) is released from a glucoside
precursor known as tuliposide A. It is the allergen in the Liliaceae and
Alstroemeriaceae family of plants.
Dermatitis is a common occupational hazard of tulip bulb handlers.
It characteristically affects the distal end of the thumb and forefingers.
This painful, dry fissured hyperkeratotic dermatitis is known as tulip
fingers.
Synonyms
a-Methylene-g-butyrolactone
a-Methylene butyrolactone
Tuliposide A
4,5-Dihydro-3-methylene-2(3H)-furanone
alpha-Methylene--gamma-butyrolactone
Uses
Plant allergen
Cross-Reactions
Unusual Reactions
Depigmentation
References
1.
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Benezra, C.,
Synthetic alpha-methylene-gammabutyrolactone, immunological
activity. Contact Dermatitis, 1978. 4(4): p. 242.
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2.
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Stampf,
J.L., G. Schlewer, and C. Benezra, Animal and human sensitivity
to alpha-methylene-gamma-butyrolactone derivatives. Contact Dermatitis,
1978. 4(5): p. 306-7.
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3.
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Stampf,
J.L., et al., Allergic contact dermatitis due to sesquiterpene
lactones. A comparative study of human and animal sensitivity to alpha-methylene-gamma-butyrolactone
and derivatives. British Journal of Dermatology, 1978. 99(2):
p. 163-9.
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4.
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Santucci, B., et al.,
Contact dermatitis to Alstroemeria.
Contact Dermatitis, 1985. 12(4): p. 215-9.
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5.
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Schaeffer, M., et al.,
Cross-reaction in allergic contact dermatitis
from alpha-methylene-gamma-butyrolactones: importance of the cis or trans
ring junction. Contact Dermatitis, 1990. 22(1): p. 32-6.
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6.
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Gette,
M.T. and J.E. Marks, Jr., Tulip fingers. Archives
of Dermatology, 1990. 126(2): p. 203-5.
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7.
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Marks,
J.G., Jr., Allergic contact dermatitis to Alstroemeria.
Archives of Dermatology, 1988. 124(6): p. 914-6.
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8.
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Thiboutot,
D.M., B.H. Hamory, and J.G. Marks, Jr., Dermatoses
among floral shop workers. Journal of the American Academy of Dermatology,
1990. 22(1): p. 54-8.
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9.
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Lahti, A.,
Contact urticaria and respiratory symptoms from tulips
and lilies. Contact Dermatitis, 1986. 14(5): p. 317-9.
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10.
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Bruynzeel,
D.P., et al., Dermatitis in bulb growers. Contact
Dermatitis, 1993. 29(1): p. 11-5.
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13-08-2011
(JRM) - www.huidziekten.nl
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