| Formula |
CAS |
| C15H20O2 |
546-43-0 |
BackgroundAlantolactone is a sesquiterpene lactone. It is a component of Helenin, a phytochemical mixture found in many plant species, including the Inula helenium (elecampane) of the family Asteraceae. Helenin is a mixture of two isomeric sesquiterpene lactones, alantolactone and isoalantolactone.
SynonymsAlantolactone
[3aR-(3aa,5b,8ab,9aa)]-3a,5,6,7,8,8 a,9,9a-Octahydro-5,8a-dimethyl-3-methylenenaphtho-[2,3-b]furan-2(3H)-one
8b-hydroxy-4aH-eudesm-5-en-12-oic aic
g-lactone
Helenin
Alant camphor
Elecampane camphor
Inula camphor
Eupatal
UsesChrysanthemum (Helenin)
Mums
Helenin
Inula helenium
Cross-Reactions
Unusual Reactions
Back to list of contact allergens
Referenties
| 1. |
Roed-Petersen J, Hjorth N. Compositae
sensitivity among patients with contact dermatitis: value of
compositae oleoresins in a standard test series. Contact
Dermatitis 1976;2(5):271-281. |
| 2. |
Campolmi P, Sertoli A, Fabbri P,
Panconesi E. Alantolactone sensitivity in chrysanthemum contact
dermatitis. Contact Dermatitis 1978;4(2):93-102. |
| 3. |
Stampf JL, Schlewer G, Ducombs G,
Foussereau J, Benezra C. Allergic contact dermatitis due to
sesquiterpene lactones. A comparative study of human and animal
sensitivity to alpha-methylene-gamma-butyrolactone and
derivatives. Br J Dermatol 1978;99(2):163-169. |
| 4. |
Stampf JL, Benezra C, Klecak G, Geleick
H, Schulz KH, Hausen B. The sensitizing capacity of helenin and
of two of its main constituents, the sesquiterpene lactones
alantolactone and isoalantolactone: a comparison of epicutaneous
and intradermal sensitizing methods in different strains of
guinea pig. Contact Dermatitis 1982;8(1):16-24. |
| 5. |
Fernández de Corres L. Contact dermatitis
from Frullania, Compositae and other plants. Contact Dermatitis
1984;11(2):74-79. |
Auteur(s):dr. Jan R. Mekkes. Dermatoloog, Amsterdam
UMC.
ICD10: L23.9