Formula |
CAS |
C28H37ClO7 |
66734-13-2 |
BackgroundAlclomethasone-17,21-dipropionate is a mild
potency topical non-fluorinated
corticosteroid
with low systemic effects. It has been used since 1986 for the treatment of
corticosteroid responsive dermatoses. It is ranked in Class III based on potency
and has been classified as a group 3 corticosteroid. Patch-test reactions occur
6-7 times more frequently within well-defined groups of structurally related
chemicals than between corticosteroids of different groups.
Synonyms
Alclomethasone-17,21-dipropionate
Alclovate
Aclosone
7-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
7a-Chloro-16a-methyl-prednisolone
UsesTopical anti-inflammatory
Cross-ReactionsGroup 3 Corticosteroids
Alclomethasone dipropionate
Beclomethason
Betamethasone valerate
Betamethasone
dipropionate
Clobetasol
Clobetasone-17-butyrate
Clobetasone-17-propionate
Fluticason
Mometason
Betamethason
Betamethasondinatriumfosfate
Desoximethason
Dexamethason
Diflucortolon
Flumetason
Hydrocortisone-17-butyrate
Hydrocortisone-17-valerate
Unusual Reactions
Back to list of contact allergens
Referenties
1. |
Dooms-Goossens AE, Degreef HJ, Mariën KJ,
Coopman SA. Contact allergy to corticosteroids: a frequently missed
diagnosis? J Am Acad Dermatol 1989;21(3 Pt 1):538-543. |
2. |
Coopman S, Degreef H, Dooms-Goossens A. Identification
of cross-reaction patterns in allergic contact dermatitis from topical
corticosteroids. Br J Dermatol 1989;121(1):27-34. |
3. |
Kabasawa Y, Kanzaki T. Allergic contact dermatitis
from alclometasone dipropionate. Contact Dermatitis 1990;23(5):374-375. |
4. |
Blancas R, Ancona A, Arévalo
A. Allergic contact dermatitis from alclomethasone dipropionate.
American Journal of Contact Dermatitis 1995;6(2):115-116. |
5. |
Lepoittevin JP, Drieghe J, Dooms-Goossens
A. Studies in patients with corticosteroid contact allergy. Understanding
cross-reactivity among different steroids. Arch Dermatol 1995;131(1):31-37. |
Auteur(s):dr. Jan R. Mekkes. Dermatoloog, Amsterdam
UMC.