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Formula |
CAS |
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C66H103N17O16S |
1405-87-4 |
CAS: Chemical Abstract Service Registry Number
Background
Bacitracin is an antibiotic polypeptide complex produced by Bacillus subtillis and Bacillus licheniformis and is effective against gram-positive organisms and spirochetes. Bacitracin inhibits bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphate. Commercial bacitracin is a mixture of at least nine bacitracins. Bacitracin A is the major component of commercial bacitracins. Bacitracin appears to be a particularly common allergen in leg ulcer treatment and post-operatively.
Synonyms
Ayfivin
Altracin
Ayfivin
Baciguent
Baci-Jel
Baciliquin
Bacitek Ointment
Bacitracin
Bacitracin zinc
Fortracin
Parentracin
Penitracin
Topitracin
Zutracin
Uses
Antibacterial ointments and creams
Ear ointments or drops
Eye ointments or drops
Cross-Reactions
Polymyxin B sulfate
Neomycin sulfate
Unusual Reactions
Immunologic contact urticaria
Anaphylaxis
Productkenmerken (Summary in Dutch)
Bacitracine is een antibioticum dat voornamelijk werkzaam is tegen grampositieve micro-organismen (waaronder streptokokken, pneumokokken en enterokokken). Het wordt in Nederland gebruikt in lokale antibacteriële producten zoals oogdruppels, oogzalven, keel-zuigtabletten, wondverzorgingsproducten, Bacicoline-B oordruppels en in over the counter producten. Soms in combinatie met neomycine. Bacitracine kan een contacteczeem veroorzaken en is opgenomen in de antibiotica-reeks.
Allergeen testsubstantie: Bacitracin 20% Van der Bend E2151 (reeks: antibiotica)
References
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1. |
Binnick AN, Clendenning WE. Bacitracin contact dermatitis [letter]. Contact Dermatitis 1978;4(3):180-181. |
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2. |
Fraki JE, Peltonen L, Hopsu-Havu VK. Allergy to various components of topical preparations in stasis dermatitis and leg ulcer. Contact Dermatitis 1979;5(2):97-100. |
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3. |
Held JL, et al. Allergic contact dermatitis from bacitracin. Journal of the American Academy of Dermatology 1987;17(4):592-594. |
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4. |
Katz BE, Fisher AA. Bacitracin: a unique topical antibiotic sensitizer. Journal of the American Academy of Dermatology 1987;17(6):1016-1024. |
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5. |
Grandinetti PJ, Fowler Jr JF. Simultaneous contact allergy to neomycin, bacitracin, and polymyxin. Journal of the American Academy of Dermatology 1990;23(4 Pt 1):646-647. |
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6. |
Gette MT, Marks Jr JG, Maloney ME. Frequency of postoperative allergic contact dermatitis to topical antibiotics. Archives of Dermatology 1992;128(3):365-367. |
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7. |
Zaki I, Shall L, Dalziel KL. Bacitracin: a significant sensitizer in leg ulcer patients? Contact Dermatitis 1994;31(2):92-94. |
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8. |
Farley M, et al. Anaphylaxis to topically applied bacitracin. American Journal of Contact Dermatitis 1995;6(1):28-31. |
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9. |
Storm DR. N Y Acad Sci 1974;235:387. |
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10. |
Craig LC, et. al. Ciba Foundation Symposium on Amino Acids and Peptides with Antimetabolic Activity, G. E. W. Wolstenholme and C.M. O'Connor, Eds., pp. 226-246, Little & Brown, Boston (1958). |
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11. |
Weinberg ED. Antibiotics. In Gottlieb D, Shaw PD (eds)., pp. 90-99 and 240-245, Springer Verlag, New York (1967). |
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12. |
Storm DR, Toscano Jr WA. Antibiotics, Vol. 5, Part 1, pp. 1-17, F. E. Hahn, Ed., Springer Verlag, New York (1979). |
03-06-2011
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