Formula |
CAS |
C9H8O |
104-55-2 |
CAS: Chemical Abstract Service Registry Number
Background
Cinnamic aldehyde is a naturally occuring fragrance with the strong odor
of cinnamon. It is found in cinnamon leaves, cinnamon bark, and the essential
oils of hyacinth, myrrh, Bulgarian rose, patchouli, and other plants.
Cinnamic aldehyde is used as a fragrance in cosmetics and over-the-counter
drugs as well as a flavoring agent in beverages, chewing gum, mouthwashes,
and toothpaste.
Oral symptoms from toothpaste containing cinnamic aldehyde include
sore mouth, dermatitis of the lips and perioral skin, swelling of the tongue,
and mouth ulceration.
The International Fragrance Association recommends that cinnamic aldehyde
be used with an equal proportion by weight of eugenol or d-limonene to
prevent sensitization. This process is known as quenching.
Synonyms
2-Propenal-3-phenyl
3-Phenyl-2-propenal
Cinnamal (CTFA adopted name)
Cinnamaldehyde
Cinnamic aldehyde
Phenylacrolein
Uses
Balsam of Tolu and Balsam of Peru
Cinnamon, Ceylon, and Cassia oil
Foods (cola, chocolate, ice cream, chewing gums)
Fragranced household products such as deodorizers, detergents, and
soaps
Perfumes
Plants (hyacinth, etc.)
Spices
Toothpaste
Cross-Reactions
Cinnamic acid
Cinnamic alcohol
Cinnamon oil
Unusual Reactions
Depigmentation
Non immunologic Contact urticaria
Photoallergy
References
1.
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Calnan,
C.D.,
Cinnamon dermatitis from an ointment. Contact Dermatitis,
1976. 2(3): p. 167-70.
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2.
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Drake, T.E. and H.I. Maibach, Allergic contact dermatitis and
stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Archives
of Dermatology, 1976. 112(2): p. 202-3.
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3.
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Fisher, A.A. and A. Dooms-Goossens, The effect of perfume "ageing"
on the allergenicity of individual perfume ingredients. Contact Dermatitis,
1976. 2(3): p. 155-9.
|
4.
|
Kirton, V., Contact urticaria and cinnamic aldehyde. Contact
Dermatitis, 1978. 4(6): p. 374-5.
|
5.
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Romaguera, C. and F. Grimalt, Sensitization to cinnamic aldehyde
in toothpaste. Contact Dermatitis, 1978. 4(6): p. 377-8.
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6.
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Mathias, C.G., R.R. Chappler, and H.I. Maibach,
Contact urticaria
from cinnamic aldehyde. Archives of Dermatology, 1980. 116(1):
p. 74-6.
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7.
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Fergurson, J. and S. Sharma, Cinnamic aldehyde test concentrations
[letter]. Contact Dermatitis, 1984. 10(3): p. 191-2.
|
8.
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Guin, J.D., et al., The effect of quenching agents on contact
urticaria caused by cinnamic aldehyde. Journal of the American Academy
of Dermatology, 1984. 10(1): p. 45-51.
|
9.
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Malten, K.E., et al., Reactions in selected patients to 22 fragrance
materials. Contact Dermatitis, 1984. 11(1): p. 1-10.
|
10.
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Maibach, H.I., Cheilitis: occult allergy to cinnamic aldehyde.
Contact Dermatitis, 1986. 15(2): p. 106-7.
|
11.
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Nethercott, J.R., et al., Contact dermatitis due to cinnamic
aldehyde induced in a deodorant manufacturing process. Contact Dermatitis,
1983. 9(3): p. 241-2.
|
12.
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Storrs, F.J., et al., Prevalence and relevance of allergic reactions
in patients patch tested in North America--1984 to 1985. Journal of
the American Academy of Dermatology, 1989. 20(6): p. 1038-45.
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13.
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Weibel, H. and J. Hansen, Penetration of the fragrance compounds,
cinnamaldehyde and cinnamyl alcohol, through human skin in vitro. Contact
Dermatitis, 1989. 20(3): p. 167-72.
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14.
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Speight, E.L. and C.M. Lawrence, Cinnamic aldehyde 2% pet. is
irritant on patch testing. Contact Dermatitis, 1990. 23(5):
p. 379-80.
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15.
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Meding, B., Skin symptoms among workers in a spice factory.
Contact Dermatitis, 1993. 29(4): p. 202-5.
|
16.
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Helton, J. and F. Storrs, The burning mouth syndrome: lack of
a role for contact urticaria and contact dermatitis. Journal of the
American Academy of Dermatology, 1994. 31(2 Pt 1): p. 201-5.
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17.
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Seite-Bellezza, D., F. el Sayed, and J. Bazex, Contact urticaria
from cinnamic aldehyde and benzaldehyde in a confectioner. Contact
Dermatitis, 1994. 31(4): p. 272-3.
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18.
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Johansen, J.D. and T. Menne, The fragrance mix and its constituents:
a 14-year material. Contact Dermatitis, 1995. 32(1): p. 18-23.
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19.
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Manzur, F., F. el Sayed, and J. Bazex, Contact allergy to cinnamic
aldehyde and cinnamic alcohol in Oleophytal. Contact Dermatitis, 1995. 32(1): p. 55.
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