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Formula |
CAS |
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C25H32ClFO5 |
25122-46-7 |
CAS: Chemical Abstract Service Registry Number
Background
Clobetasol-17-propionate is a high-potency topical fluorinated corticosteroid with low systemic effects. It has been classified as group D by Coopman et al. According the A-D grouping, patch-test reactions occur 6-7 times more frequently within well-defined groups of structurally related chemicals than between corticosteroids of different groups.
Synonyms
Clobetasol-17-propionate
Clobetasol
(11b,16b)-21-chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
Clobesol
Dermoval
Dermovate
Dermoxin
Dermoxinale
Temovate
Uses
Anti-inflammatory
Pharmaceutical
Cross-Reactions
Goup D Corticosteroids
Alclomethasone dipropionate
Betamethasone dipropionate
Betamethasone valerate
Clobetasone-17-butyrate
Clobetasone-17-propionate
Fluocortolone caproate
Fluocortolone pivalate
Fluprenidene acetate
Hydrocortisone-17-butyrate
Hydrocortisone-17-valerate
Unusual Reactions
Contact urticaria
References
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1. |
van Ketel, W.G. and A.F. Swain, Allergy to clobetasol-17-propionate (Dermovate). Contact Dermatitis, 1981. 7(5): p. 278-9. |
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2. |
Forstrom, L., et al., Allergic contact eczema from topical corticosteroids. Contact Dermatitis, 1982. 8(2): p. 128-33. |
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3. |
Chalmers, R.J., M.H. Beck, and H.L. Muston, Simultaneous hypersensitivity to clobetasone butyrate and clobetasol propionate. Contact Dermatitis, 1983. 9(4): p. 317-8. |
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4. |
Boyle, J. and R.D. Peachey, Allergic contact dermatitis to Dermovate and Eumovate. Contact Dermatitis, 1984. 11(1): p. 50-1. |
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5. |
Spiro, J.G. and C.M. Lawrence, Contact sensitivity to clobetasol propionate. Contact Dermatitis, 1986. 14(2): p. 116-7. |
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6. |
Tosti, A., et al., Contact dermatitis from clobetasol propionate. Contact Dermatitis, 1987. 17(4): p. 256-7. |
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7. |
Cox, N.H., Contact allergy to clobetasol propionate. Archives of Dermatology, 1988. 124(6): p. 911-3. |
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8. |
Coopman, S., H. Degreef, and A. Dooms-Goossens, Identification of cross-reaction patterns in allergic contact dermatitis from topical corticosteroids. British Journal of Dermatology, 1989. 121(1): p. 27-34. |
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9. |
Dunkel, F.G., P. Elsner, and G. Burg, Contact allergies to topical corticosteroids: 10 cases of contact dermatitis. [Review]. Contact Dermatitis, 1991. 25(2): p. 97-103. |
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10. |
Lepoittevin, J.P., J. Drieghe, and A. Dooms-Goossens, Studies in patients with corticosteroid contact allergy. Understanding cross-reactivity among different steroids [see comments]. Archives of Dermatology, 1995. 131(1): p. 31-7. |
21-07-2011
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