|
Formula |
CAS |
|
C6H14N4O7 |
78491-02-8 |
CAS: Chemical Abstract Service Registry Number
Background
Diazolidinylurea (Germall 11) is broad-spectrum preservative used in cosmetics
and pharmaceutical preparations. It is especially active against gram-negative
bacteria and is often combined with parabens.
Diazolidinylurea is the newest and most active member of the imidazolidinyl
urea group. It has been used since 1982. Diazolidinylurea may be a stronger
sensitizer than imidazolidinyl urea.
Synonyms
2,5-Diazolidinylurea
Diazolidinyl Urea
Germaben II
Germall II
N,N'-Bis (hydroxymethyl) urea
N-(hydroxymethyl)-N-(1,3-dihydroxymethyl-2,5-dioxo-4-imidazolidinyl)-N'- (hydroxymethyl) urea
Uses
Preservative used in cosmetics, creams and lotions
Cross-Reactions
Imidazolidinylurea
Formaldehyde
Unusual Reactions
References
|
1. |
Kantor, G.R., et al., Acute allergic contact dermatitis from diazolidinyl urea (Germall II) in a hair gel. Journal of the American Academy of Dermatology, 1985. 13(1): p. 116-9. |
|
2. |
Stephens, T.J., K.D. Drake, and R.B. Drotman, Experimental delayed contact sensitization to diazolidinyl urea (Germall II) in guinea pigs. Contact Dermatitis, 1987. 16(3): p. 164-8. |
|
3. |
Zaugg, T. and T. Hunziker, Germall II and triclosan [letter]. Contact Dermatitis, 1987. 17(4): p. 262. |
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4. |
de Groot, A.C., et al., Contact allergy to diazolidinyl urea (Germall II). Contact Dermatitis, 1988. 18(4): p. 202-5. |
|
5. |
Nethercott, J.R., G. Nield, and D.L. Holness, A review of 79 cases of eyelid dermatitis. Journal of the American Academy of Dermatology, 1989. 21(2 Pt 1): p. 223-30. |
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6. |
Tosti, A., S. Restani, and M. Lanzarini, Contact sensitization to diazolidinyl urea: report of 3 cases. Contact Dermatitis, 1990. 22(2): p. 127-8. |
|
7. |
Hectorne, K.J. and A.F. Fransway, Diazolidinyl urea: incidence of sensitivity, patterns of cross-reactivity and clinical relevance. Contact Dermatitis, 1994. 30(1): p. 16-9. |
13-08-2011
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