|
Formula |
CAS |
|
C2H10Cl2N2 |
333-18-6 |
CAS: Chemical Abstract Service Registry Number
Background
Ethylenediamine dihydrochloride is a solvent for casein, albumin, shellac, and sulfur. It is a stabilizer in rubber latex and pharmaceuticals, an inhibitior in antifreeze solutions, and emulsifier.
Synonyms
1,2-Diaminoethane
1,2-Ethanediamine
Chlor-ethamine
Ethylenediamine dihydrochloride
Proxel CRL (1,2-Benzisothiazolin-3-one + ethylenediamine)
Uses
Aminophylline: theophylline plus
ethylenediamine.
Inhibitor in antifreeze solutions and cooling fluids
Antihistamines: piperazine-based antihistamines, which are closely
related to ethylenediamine, are a well-recognized cause of sensitivity.
These include meclizine (Bonine, Antivert), buclizine (Bucladin-S); chlorcyclizine
(Fedrazil, Mantadil), and cyclizine (Marezine, Migral). Other ethylenediamine-related
antihistamines rarely cause sensitivity in ethylenediamine-sensitive individuals.
These derivatives include antazoline (Antistine), chlorothen citrate (Tagathen),
methapyrilene hydrochloride (Histadyl), pyrilamine maleate (Pyma), and
tripelennamine citrate and hydrochloride (Pyribenzamine).
Color developers.
Dyes.
Electroplating and electrophoretic gels.
Emulsifier.
Epoxy and textile resins.
Eye and nose drops.
Floor polish remover.
Fungicides and insecticides.
Nystatin creams: deleted from Mycolog Cream but still present in generic
nystatin creams in the United States as well as brand name nystatin creams
in Europe and elsewhere. Nystex® Cream (Savage); Nystatin® Cream (Fougera,
Pharmaderm, Lemmon); and Myco-Triacet Cream (Lemmon).
Proxel CRL (1,2-Benzisothiazolin-3-one + ethylenediamine)
Rubber latex stabilizer.
Solvent for casein, albumin, shellac, and sulfur.
Synthetic waxes.
Textile lubricant.
Thimerosal (Tincture of Merthiolate).
Veterinary preparations.
Cross-Reactions
Aminophylline
Antazoline
Piperazine
Promethazine HCl
Diethylenetriamine
Triethylenetetramine
Unusual Reactions
Contact urticaria
Erythema multiforme-like
References
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1. |
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2. |
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4. |
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8. |
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10. |
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11. |
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13. |
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18. |
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19. |
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20. |
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21. |
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22. |
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|
26. |
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|
27. |
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|
28. |
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29. |
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|
30. |
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31. |
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|
32. |
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|
33. |
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|
34. |
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|
35. |
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|
36. |
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|
37. |
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|
38. |
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|
39. |
Eedy, D.J., Angioneurotic oedema following piperazine ingestion in an ethylenediamine-sensitive subject. Contact Dermatitis, 1993. 28(1): p. 48-9. |
|
40. |
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|
41. |
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|
42. |
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|
43. |
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