Fragrance mix

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CAS: Chemical Abstract Service Registry Number


The fragrance mix is composed of  Amylcinnamaldehyde, Cinnamic aldehyde, Cinnamic alcohol, Eugenol, Isoeugenol, Geraniol, Hydroxycitronellal and  Oakmoss absolute.
The fragrance mix is used to screen for contact allergy to fragrances. The term fragrance means any natural or synthetic substance or substances used solely to impart an odor to a cosmetic product. Natural fragrances are usually of botanical origin and may contain several hundred different chemicals (such as balsams, esential oils and spices like cinnamon, cloves, vanilla and cardamom). Over 90% of all fragrances used is synthetic. Although many fragrances are thus not included in the fragrance mix, the mix correlates well with contact allergies to fragrances in general.
Fragrance-free does not guarantee that the product does not contain any fragrance products. The ROAT is recommended to test stay-on cosmetics.



Aroma chemicals
Essential oils of plants and animals
Fragrance mix
Masking or unscented perfumes
Toilet water



Cosmetics, oral hygiene products
Topical medications like ointments and suppositories
Household products (room fresheners, waxes, polishes, cleaning agents, insect repellents, washing powders and softeners, etc.)
Industrial exposure (metalworking fluids, paints, rubber, plastics, insecticides, herbicides, etc.)
Paper products, fabric, clothes
Flavors (candy, soft drinks, foods)

Technical fluids





Unusual Reactions

Fragrances may cause photo-allergic reactions. Pseudoallergic immediate reactions may relate to redness, itching and tingling within 5-10 minutes of application of mainly cinnamic aldehyde, benzoic acid and sorbic acid in cosmetics and occur as high as in 17% of tested individuals, 10% of these reactions are followed by a delayed type reaction on the fragrance-mix.




Lynde, CW, Mitchell JC. Patch testing with balsam of Peru and fragrance mix. Contact Dermatitis, 1982. 8(4): p. 274-7.


Malten, KE, et al. Reactions in selected patients to 22 fragrance materials. Contact Dermatitis, 1984. 11(1): p. 1-10.


de Groot AC, et al. Patch tests with fragrance materials and preservatives. Contact Dermatitis, 1985. 12(2): p. 87-92.


Larsen WG. Perfume dermatitis. Journal of the American Academy of Dermatology, 1985. 12(1 Pt 1): p. 1-9.


Enders F, Przybilla B, Ring J. Patch testing with fragrance mix at 16% and 8%, and its individual constituents. Contact Dermatitis, 1989. 20(3): p. 237-8.


Safford RJ, et al. Immediate contact reactions to chemicals in the fragrance mix and a study of the quenching action of eugenol. British Journal of Dermatology, 1990. 123(5): p. 595-606.


de Groot AC, et al. Frequency of false-negative reactions to the fragrance mix. Contact Dermatitis, 1993. 28(3): p. 139-40.


Becker K, Temesvari E, Nemeth I. Patch testing with fragrance mix and its constituents in a Hungarian population. Contact Dermatitis, 1994. 30(3): p. 185-6.


Johansen JD Menne T. The fragrance mix and its constituents: a 14-year material. Contact Dermatitis, 1995. 32(1): p. 18-23.


Katsarou A, Armenaka M, Kalogeromitros D et al. Contact reactions to fragrances. Ann Allergy Asthma Immunol 1999;82:449-455


Larsen WG, et al. Fragrance contact dermatitis: a worldwide multicenter investigation (part I). Am J Contact Dermatitis 1996;77-83


Scheinman P. The foul side of fragrance-free products. J.Am Acad Dermatol 1999;41:1020-1024






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