|
Formula |
CAS |
|
C5H8O2 |
111-30-8 |
CAS: Chemical Abstract Service Registry Number
Background
Glutaraldehyde is an aliphatic dialdehyde, soluble in water, alcohol, and
other solvents. At 2% it is employed as a cold sterilizer for many instruments
in hospitals. Unbuffered solutions are stable and have little antimicrobial
potential. When sodium bicarbonate is added, an alkaline pH results and
a strong antimicrobial is obtained. Its antiviral, fungicidal and bactericidal
activity is enhanced, but it reamins stable only for 10 to 15 days.
Glutaraldehyde is used pharmacologically to treate hyperhidrosis, fungal
infections, and warts. It causes brown discoloration of the skin. It is
a strong irritant as well as allergic sensitizer.
Synonyms
1,3-Diformylpropane
1,5-Pentanedial
Alhydex
Cidex
Dioxopentane
Glutaral (CTFA adopted name)
Glutaraldehyde
Glutaaraldehyde
Glutardialdehyde
Glutaric dialdehyde
Glutarol
Pentanedial
Sporicidin
Ucarcide
Veruca-sep
Uses
Allergy and collagen extracts
Cosmetics
Dental and barber equipment
Electron microscopy
Embalming fluid
Leather tanning
Pharmaceutrical for hyperhidrosis and warts
Sterilization for medical, dental, and barber equipment
Topical medicaments
X-ray and photographic solutions
Cross-Reactions
Unusual Reactions
Airborne contact dermatitis
References
|
1. |
Jordan, W.P., Jr., M. Dahl, and H.L. Albert, Contact dermatitis from glutaraldehyde. Archives of Dermatology, 1972. 105(1): p. 94-5. |
|
2. |
Maibach, H.I. and S.D. Prystowsky, Glutaraldehyde (pentanedial) allergic contact dermatitis. Usage test on sole and antecubital fossa: regional variations in response. Archives of Dermatology, 1977. 113(2): p. 170-1. |
|
3. |
Weaver, J.E. and H.I. Maibach, Dose response relationships in allergic contact dermatitis: glutaraldehyde-containing liquid fabric softener. Contact Dermatitis, 1977. 3(2): p. 65-8. |
|
4. |
Hansen, K.S., Occupational dermatoses in hospital cleaning women. Contact Dermatitis, 1983. 9(5): p. 343-51. |
|
5. |
Hansen, K.S., Glutaraldehyde occupational dermatitis. Contact Dermatitis, 1983. 9(1): p. 81-2. |
|
6. |
Goncalo, S., et al., Occupational contact dermatitis to glutaraldehyde. Contact Dermatitis, 1984. 10(3): p. 183-4. |
|
7. |
Bardazzi, F., et al., Glutaraldehyde dermatitis in nurses. Contact Dermatitis, 1986. 14(5): p. 319-20. |
|
8. |
Di Prima, T., R. De Pasquale, and M. Nigro, Contact dermatitis from glutaraldehyde. Contact Dermatitis, 1988. 19(3): p. 219-20. |
|
9. |
Nethercott, J.R. and D.L. Holness, Contact dermatitis in funeral service workers. Contact Dermatitis, 1988. 18(5): p. 263-7. |
|
10. |
Nethercott, J.R., D.L. Holness, and E. Page, Occupational contact dermatitis due to glutaraldehyde in health care workers. Contact Dermatitis, 1988. 18(4): p. 193-6. |
|
11. |
Fisher, A.A., Allergic contact dermatitis of the hands from Sporicidin (glutaraldehyde-phenate) used to disinfect endoscopes. Cutis, 1990. 45(4): p. 227-8. |
|
12. |
Hansen, E.M. and T. Menne, Glutaraldehyde: patch test, vehicle and concentration. Contact Dermatitis, 1990. 23(5): p. 369-70. |
|
13. |
Mellstrom, G., Protective gloves of polymeric materials. Experimental permeation testing and clinical study of side effects. Acta Dermato-Venereologica. Supplementum, 1991. 163: p. 1-54. |
|
14. |
Mellstrom, G.A., M. Lindberg, and A. Boman, Permeation and destructive effects of disinfectants on protective gloves. Contact Dermatitis, 1992. 26(3): p. 163-70. |
|
15. |
Cusano, F. and S. Luciano, Contact allergy to benzalkonium chloride and glutaraldehyde in a dental nurse. Contact Dermatitis, 1993. 28(2): p. 127. |
|
16. |
Lehman, P.A., T.J. Franz, and J.D. Guin, Penetration of glutaraldehyde through glove material: Tactylon versus natural rubber latex. Contact Dermatitis, 1994. 30(3): p. 176-7. |
12-11-2011
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