CAS: Chemical Abstract Service Registry Number
Background
The parabens are the most widely used preservatives in food, drugs, and cosmetics.
The paraben mix is used in commercial patch-test series to detect contact allergy this group of closely related preservatives. These allergens include Benzylparaben, Butylparaben,
Ethylparaben, Methylparaben, and Propylparaben.
Synonyms
Aseptoform
Benzylparaben
Butylparaben
Ethylparaben
Germaben II (mixture)
Lexgard
Methylparaben
Nipagin
Nipastat (mixture)
p-Hydroxybenzoate
p-Hydroxybenzoic acid
Parabens
ParaseptLiqua par
Perservaben
Phenonip (mixture)
Propylparaben
Protaben
Undebenzofene-C (mixture)
Benzyl-4-hydroxybenzoate
Methyl-4-hydroxybenzoate
Ethyl-4-hydroxybenzoate
Propyl-4-hydroxybenzoate
Butyl-4-hydroxybenzoate
Uses
Cosmetics
Medicines (topical and systemic)
Foods (marinated fish products, mayonnaise, salad dressings, spiced sauces, mustard, processed vegetables, frozen dairy products, baked goods)
Industrial (oils, fats, glues, shoe polish, textiles)
Cross-Reactions
Unusual Reactions
References
1.
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Schamberg, I.L., Allergic contact dermatitis to methyl and propyl paraben. Archives of Dermatology, 1967. 95(6): p. 626-8.
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2.
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Fisher, A.A., F. Pascher, and N.B. Kanof, Allergic contact dermatitis due to ingredients of vehicles. A "vehicle tray" for patch testing.
Archives of Dermatology, 1971. 104(3): p. 286-90.
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3.
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Aeling, J.L. and D.D. Nuss, Letter: Systemic eczematous "contact-type" dermatitis medicamentosa caused by parabens. Archives of Dermatology,
1974. 110(4): p. 640.
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4.
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Hannuksela, M., M. Kousa, and V. Pirila, Allergy to ingredients of vehicles. Contact Dermatitis, 1976. 2(2): p. 105-10.
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5.
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6.
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9.
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Fisher, A.A., Paraben dermatitis due to a new medicated bandage: The "paraben paradox". Contact Dermatitis, 1979. 5(4): p. 273-4.
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10.
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11.
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14.
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16.
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17.
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18.
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19.
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20.
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21.
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22.
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23.
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24.
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Seidenari, S., et al., Patch and prick test study of 593 healthy subjects. Contact Dermatitis, 1990. 23(3): p. 162-7.
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25.
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Fisher, A.A., A "current contact news" follow-up: controversial subjects and those resulting in litigation [news]. Cutis, 1993. 52(5): p. 254-6.
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26.
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Wurbach, G., H. Schubert, and I. Phillipp, Contact allergy to benzyl alcohol and benzyl paraben. Contact Dermatitis, 1993. 28(3): p. 187-8.
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27.
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Perrenoud, D., et al., Frequency of sensitization to 13 common preservatives in Switzerland. Swiss Contact Dermatitis Research Group. Contact Dermatitis,
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28.
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Rastogi, S.C., et al., Contents of methyl-, ethyl-, propyl-, butyl- and benzylparaben in cosmetic products. Contact Dermatitis, 1995. 32(1): p. 28-30.
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20-08-2011
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