Tetramethylthiuram monosulfide

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CAS: Chemical Abstract Service Registry Number


Tetramethylthiuram monosulfide is an accelerator and activator for natural rubber nitrile-butadiene, and butyl rubber.



Tetramethylthiuram monosulfide



Condoms and diaphragms
Disinfectants, repellents, fungicides, and insecticides in agriculture
DIsulfiram (Antabuse)
Gloves (household, work, or hospital)
Leather shoes (insoles, adhesives, linings)
Medical devices
Natural rubber nitrile-butadiene and butyl rubber
Renal dialysis equipment
Rubber in undergarments and clothing
Rubber pillows and sheets
Rubber shoes (sneakers, tennis shoes, etc.)
Soaps and shampoos
Sponge makeup applicators and rubber eyelash curiers
Swimwear and toys
Tires and tubes



Tetramethylthiuram disulfide


Unusual Reactions





Penneys, N.S., L.S. Edwards, and J.L. Katsikas, Allergic contact sensitivity to thiuram compounds in a hemodialysis unit. Archives of Dermatology, 1976. 112(6): p. 811-3.


van Ketel, W.G., Thiuram-mix. Contact Dermatitis, 1976. 2(4): p. 232-3.


Menne, T. and K. Kaaber, Treatment of pompholyx due to nickel allergy with chelating agents. Contact Dermatitis, 1978. 4(5): p. 289-90.


Bransbury, A.J., Allergy to rubber condom urinals and medical adhesives in male spinal injury patients. Contact Dermatitis, 1979. 5(5): p. 317-23.


Lachapelle, J.M. and D. Tennstedt, Epidemiological survey of occupational contact dermatitis of the hands in Belgium. Contact Dermatitis, 1979. 5(4): p. 244-8.


Barber, K.A. and E. Cronin, Patch and photopatch testing in chronic actinic dermatitis. Contact Dermatitis, 1984. 10(2): p. 69-73.


Themido, R. and F.M. Brandao, Contact allergy to thiurams. Contact Dermatitis, 1984. 10(4): p. 251.


Van Ketel, W.G., Contact urticaria from rubber gloves after dermatitis from thiurams. Contact Dermatitis, 1984. 11(5): p. 323-4.


Kruis-de Vries, M.H., P.J. Coenraads, and J.P. Nater, Allergic contact dermatitis due to rubber chemicals in haemodialysis equipment. Contact Dermatitis, 1987. 17(5): p. 303-5.


Storrs, F.J., et al., Prevalence and relevance of allergic reactions in patients patch tested in North America--1984 to 1985. Journal of the American Academy of Dermatology, 1989. 20(6): p. 1038-45.


Heese, A., et al., Allergic and irritant reactions to rubber gloves in medical health services. Spectrum, diagnostic approach, and therapy [published erratum appears in J Am Acad Dermatol 1992 Mar;26(3 Pt 2):403] [see comments]. Journal of the American Academy of Dermatology, 1991. 25(5 Pt 1): p. 831-9.


Kimber, I., et al., Lymphocyte transformation and thiuram sensitization. Contact Dermatitis, 1991. 24(3): p. 164-71.


Shehade, S.A., M.H. Beck, and V.F. Hillier, Epidemiological survey of standard series patch test results and observations on day 2 and day 4 readings. Contact Dermatitis, 1991. 24(2): p. 119-22.


von Hintzenstern, J., et al., Frequency, spectrum and occupational relevance of type IV allergies to rubber chemicals. Contact Dermatitis, 1991. 24(4): p. 244-52.


Conde-Salazar, L., et al., Type IV allergy to rubber additives: a 10-year study of 686 cases. Journal of the American Academy of Dermatology, 1993. 29(2 Pt 1): p. 176-80.


Knudsen, B.B., et al., Release of thiurams and carbamates from rubber gloves. Contact Dermatitis, 1993. 28(2): p. 63-9.






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